Alli (Orlistat) Makes me Happy and Hungry

Well, it turns out that I am not crazy (on this topic), Alli which I  have been taking, and making me feel great, actually may have some Psychological side effects – people reported Anxiety in the US drug trials, which I high level of coorolation.  Moreover, it turns out the drug manufactures do not report the actual mechanism of how it works in the literature.

It turns our that the over the counter Alli,  was originally developed as an inhibitor of pancreatic lipase by Hoffmann-La Roche & Co in 1983.   What does this mean, well it effects your hormones causing the pancrease to release a chemical in to the gastrointestinal which keeps you from obsorbing fat.

Ironically as reported in Germany – “Alli (Orlistat) alters gastric and gallbladder emptying and causes changes in gastrointestinal hormone concentrations. This may raise appetite sensations and increase food consumption1.”

Well it doesn’t take a psychiatrist to know that anything and changes hormone levels is going to have an effect on mood.

So yes, Alli makes me feel great! yep, I do eat a fourth meal at night though, but the world has changed for me.

While I maybe the only person in the world who knows that Alli(orlistat) has an off label use as an AntiDepressant, but there is evidence to support the probability of the reality of this theory.

What is different for me?

Well I am happier, I wake up at 5:45am every morning, feel great and it has been going super well.

Note from med net: Orlistat alters gastric and gallbladder emptying and reduces the postprandial secretion of GLP-1, PYY and CCK. These changes in gastrointestinal hormone concentrations may raise appetite sensations and increase food consumption and should therefore be considered as potential side effects when applying lipase inhibitors for the treatment of morbid obesity. (not that I am obese )


1. Ellrichmann M, Kapelle M, Ritter PR, Holst JJ, Herzig KH, Schmidt WE, Schmitz F, Meier JJ. Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations. J Clin Endocrinol Metab. 2008 Oct;93(10):3995-8 PubMed

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